UniprotKB/SwissProt ID: TRI23_HUMAN (P36406)
Gene Name: TRIM23
Synonyms: ARD1, ARFD1, RNF46
Organism: Homo sapiens (Human).
Function: Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.
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