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Protein Name: E3 ubiquitin/ISG15 ligase TRIM25

UniprotKB/SwissProt ID: TRI25_HUMAN (Q14258)

Gene Name: TRIM25

Synonyms: EFP, RNF147, ZNF147

Organism: Homo sapiens (Human).

Function: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001841
IPR001870
IPR003877
IPR003879
IPR006574
IPR013083

The ubiquitination sites of TRI25_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1205EATLRH K LTVMYS HHHHHH H HHHHHH 39.14%21906983
2237RMTANR K VEQLQQ HHHHHH H HHHHHH 50.35%21906983
3249QEYTEM K ALLDAS HHHHHH H HHHHHH 29.65%21906983
4273EKRVNS K FDTIYQ HHHHHH H HHHHHH 41.89%21890473
5283IYQILL K KKSEIQ HHHHHH H HHHHHH 55.50%21906983
6292SEIQTL K EEIEQS HHHHHH H HHHHHH 57.60%21906983
7301IEQSLT K RDEFEF HHHHHH C CCHHHH 64.24%21906983
8310EFEFLE K ASKLRG HHHHHH H HHHHHH 61.17%21906983
9320LRGIST K PVYIPE HHHHHC H HHHCCH 26.20%21890473
10335LNHKLI K GIHQST HHHHHH H HHHHHH 63.35%21890473
11345QSTIDL K NELKQC HHHHHH H HHHHHH 44.63%21906983
12392EEKKSK K PPPVPA HHHCCC C CCCHHH 70.60%21906983
13402VPALPS K LPTFGA HHHHHH H HHHHCC 57.45%21906983
14416EQLVDL K QAGLEA HHHHHH H HCCHHH 33.37%21906983
15425GLEAAA K ATSSHP CHHHCC C CCCCCC 47.69%21906983
16439STSLKA K VLETFL CCCCCH H HHHHHC 45.85%21906983
17509GLHCYK K GIHYWE CCCCCC C CCEEEE 36.30%21906983
18567WHNNVE K TLPSTK EECCCC C CCCCCC 51.59%2189047
The interacting network mediated by proteins: TRI25_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
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© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.