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Protein Name: E3 ubiquitin-protein ligase TRIM32

UniprotKB/SwissProt ID: TRI32_HUMAN (Q13049)

Gene Name: TRIM32

Synonyms: HT2A

Organism: Homo sapiens (Human).

Function: Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus.

PDB :
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Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000315
IPR001258
IPR001841
IPR007087
IPR011042
IPR013017
IPR013083


The ubiquitination sites of TRI32_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1175ALEGVS K DLQARY HHHHHH H HHHHHH 61.11%21890473
2182DLQARY K AVLQEY HHHHHH H HHHHHH 26.85%21906983
3204ELARSR K FFTGSL HHHHHH H HHHHHH 46.18%21890473
4215SLAEVE K SNSQVV HHHHHH H HHHHHH 61.18%21906983
5247YFLAKI K QADVAL HHHHHH H HHHHHH 38.43%21906983
6282QDVELL K VGHVGP CCCHHC C CCCCCC 59.81%21906983
7405TRKGFL K EIRRSP CCCCCE E EEEECC 49.16%21890473
8471HRSQLS K PWGITA EECCCC C CEEEEE 54.07%21890473

The interacting network mediated by proteins: TRI32_HUMAN


Disease:
Disease database Database Entry Disease information
HPRD03797Bardet-Biedl syndrome 11
HPRD03797Muscular dystrophy, limb-girdle, type 2H
Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes