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Protein Name: E3 ubiquitin-protein ligase TRIM68

UniprotKB/SwissProt ID: TRI68_HUMAN (Q6AZZ1)

Gene Name: TRIM68

Synonyms: GC109, RNF137, SS56

Organism: Homo sapiens (Human).

Function: Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR000315
IPR001841
IPR001870
IPR003877
IPR003879
IPR006574
IPR013083

The ubiquitination sites of TRI68_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
181LANVVE K VRLLRL HHHHHH H HHHCCC 22.50%21890473
2271EVLNRS K SWSLQQ HHHHHH H CCCCCC 53.35%21906983
3333YGDTNQ K LPDNPE ECCCCC C CCCCCC 65.15%2190698
The interacting network mediated by proteins: TRI68_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
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© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.