UniprotKB/SwissProt ID: TTC3_HUMAN (P53804)
Gene Name: TTC3
Synonyms: DCRR1, RNF105, TPRD
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'- polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
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