UbiNet

Protein Name: Ubiquitin-protein ligase E3A

UniprotKB/SwissProt ID: UBE3A_HUMAN (Q05086)

Gene Name: UBE3A

Synonyms: E6AP, EPVE6AP, HPVE6A

Organism: Homo sapiens (Human).

Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (Probable).

PDB :
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Graphical Visualization of Ubiquitination Sites:

Overview of Protein Ubiquitination Sites with Functional and Structural Information

InterPro ID	Domain
IPR000569

The ubiquitination sites of UBE3A_HUMAN

No.	Position	Ubiquitinated Peptide	Secondary Structure	Solvent Accessibility	Substrate Motifs	PubMed ID
1	30	MKRAAA K HLIERY	HHHHHH H HHHHHH	33.93%		21890473
2	71	NNAAAI K ALELYK	CCHHHH E EEEEEE	42.04%		20639865
3	77	KALELY K INAKLC	EEEEEE E ECCCCC	41.95%		21890473
4	90	DPHPSK K GASSAY	CCCCCC C CCCCHH	65.14%		90473
5	123	GARIDF K DVTYLT	CCCCCH H HHHHHH	47.76%		21890473
6	184	LKSLQA K DEDKDE	HHHHHH C CCCCCH	49.00%		21906983
7	226	GDNNLQ K LGPDDV	CCCHHH H CCCCCE	59.59%		2266
8	323	PLAAQG K LIRLWS	CHHHCC C EEEEEH	28.76%		21890473
9	330	LIRLWS K YNADQI	EEEEEH H CCHHHH	30.83%		21890473
10	350	QQLITY K VISNEF	HHHHHH H HHHCCC	25.17%		21890473
11	373	AIVAAS K CLKMVY	HHHHHH H HHHHHH	38.57%		21890473
12	468	KDYTFF K VETENK	HHHHHH H HHCCCC	34.66%		21890473
13	552	ENPADL K KQLYVE	CCCHHC C CEEEEE	38.73%		21906983
14	553	NPADLK K QLYVEF	CCHHCC C EEEEEE	53.48%		21906983
15	711	ITNENR K EFVNLY	CCHHHH H HHHHHH	68.06%		21890473
16	724	SDYILN K SVEKQF	HHHHHH H HHHHHH	53.05%		21890473
17	728	LNKSVE K QFKAFR	HHHHHH H HHHHHH	59.90%		21890473
18	802	SFTDEQ K RLFLQF	CCCHHH H HHHHEE	49.36%		21906983
19	829	LKMIIA K NGPDTE	CCEEEE E CCCCCC	52.62%		2190698

The interacting network mediated by proteins: UBE3A_HUMAN

Disease:

Disease database	Database Entry	Disease information
HPRD	03375	Angelman syndrome

Metabolic pathway:

Kegg map ID	Pathway
map03008	Ribosome biogenesis in eukaryotes

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