UniprotKB/SwissProt ID: UBR2_HUMAN (Q8IWV8)
Gene Name: UBR2
Synonyms: C6orf133, KIAA0349
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (By similarity). Note=Associated with chromatin during meiosis.
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