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Protein Name: E3 ubiquitin-protein ligase UBR3

UniprotKB/SwissProt ID: UBR3_HUMAN (Q6ZT12)

Gene Name: UBR3

Synonyms: KIAA2024, ZNF650

Organism: Homo sapiens (Human).

Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein (Potential).

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information


The ubiquitination sites of UBR3_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1236ADGPSE K DLNKVL   72.37%21906983
21045VAERRK K FQEIIN   50.93%21890473
31141VERILL K AASQSR   38.16%21890473
41733RHAEQG K ALLIQE   35.24%2190698

The interacting network mediated by proteins: UBR3_HUMAN


Disease:
Disease database Database Entry Disease information
OMIM613831UBIQUITIN PROTEIN LIGASE E3 COMPONENT N-RECOGNIN 3; UBR3
Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes