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Protein Name: E3 ubiquitin-protein ligase UBR4

UniprotKB/SwissProt ID: UBR4_HUMAN (Q5T4S7)

Gene Name: UBR4

Synonyms: KIAA0462, KIAA1307, RBAF600, ZUBR1

Organism: Homo sapiens (Human).

Function: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information

The ubiquitination sites of UBR4_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
1174SDVEDQ K ELASPV   68.00%21906983
2234DQASAI K TKNVFI   53.84%21906983
3366TGSTSS K EDDYES   66.00%21906983
4605ISPSKE K AAPPPP   54.29%21906983
51150AETDPH K SSEITK   62.15%21906983
61156KSSEIT K NLLPAT   51.78%21906983
71189EEGTTE K PSKEKL   53.12%21906983
81477MTTSPP K DSDQLD   73.56%21906983
91574KKYLSQ K NVVEKL   48.62%21906983
101741GMSSTM K ESAFQS   48.91%21890473
113405LNKFAD K ETLIQF   49.52%21890473
124035PTSKKN K DVPVEA   69.82%21890473
134122TSPLDL K LGHNNW   52.68%21890473
144215VGNLIT K EIARLL   39.88%2189047
The interacting network mediated by proteins: UBR4_HUMAN

Disease:
Disease database Database Entry Disease information
OMIM609890RETINOBLASTOMA-ASSOCIATED FACTOR 600 ;;RBAF600;; KIAA1307;; p600
Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
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© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.