logo
   Home | Network Analysis | Data Statistics | Quick Search by Swiss-Prot ID or Keyword

Menu:


Protein Name: Ubiquitin carboxyl-terminal hydrolase isozyme L1

UniprotKB/SwissProt ID: UCHL1_HUMAN (P09936)

Gene Name: UCHL1

Organism: Homo sapiens (Human).

Function: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note=About 30% of total UCHL1 is associated with membranes in brain.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001578

The ubiquitination sites of UCHL1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
115NPEMLN K VLSRLG CHHHHH H HHHHCC 40.36%21890473
265HENFRK K QIEELK EEECCC C CCCCCC 52.86%17259170
371KQIEEL K GQEVSP CCCCCC C CCCCCC 62.92%21906983
471KQIEEL K GQEVSP CCCCCC C CCCCCC 62.92%21906983
578GQEVSP K VYFMKQ CCCCCC C EEEEEC 41.90%21890473
683PKVYFM K QTIGNS CCEEEE E CCCCCH 34.10%83
7115EDGSVL K QFLSET CCCHHH H HHHHHH 36.53%20639865
8135RAKCFE K NEAIQA HHHHHC C CHHHHH 39.57%21906983
9157QCRVDD K VNFHFI CCEEEH E EEEEEE 34.32%21906983
10157QCRVDD K VNFHFI CCEEEH E EEEEEE 34.32%21906983
The interacting network mediated by proteins: UCHL1_HUMAN

Disease:
Disease database Database Entry Disease information
KEGGH00057 Parkinson's disease (PD)
OMIM191342UBIQUITIN CARBOXYL-TERMINAL ESTERASE L1; UCHL1 ;;UBIQUITIN C-TERMINAL HYDROLASE, NEURON-SPEC
OMIM613643PARKINSON DISEASE 5, AUTOSOMAL DOMINANT; PARK5
HPRD01877Parkinson disease
HPRD01877Parkinson disease, resistance to
Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes
 
Version 1.0
© UbiNet's Team: Van-Nui Nguyen, Kai-Yao Huang, Prof. Tzong-Yi Lee, and Prof. K. Robert Lai: Department of Computer Science and Engineering, Yuan Ze University.