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Protein Name: E3 UFM1-protein ligase 1

UniprotKB/SwissProt ID: UFL1_HUMAN (O94874)

Gene Name: UFL1

Synonyms: KIAA0776, NLBP

Organism: Homo sapiens (Human).

Function: E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum. Cytoplasm. Note=In cytoplasm colocalizes with CDK5RAP3.

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information


The ubiquitination sites of UFL1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
143NKLIAQ K QLEVVH   48.07%2189047

The interacting network mediated by proteins: UFL1_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes