UniprotKB/SwissProt ID: UHRF2_HUMAN (Q96PU4)
Gene Name: UHRF2
Synonyms: NIRF, RNF107
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Enriched at pericentric heterochromatin (PH). This localization is dependent on the interaction with H3K9me3 (By similarity).
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