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Protein Name: WD repeat and SOCS box-containing protein 1

UniprotKB/SwissProt ID: WSB1_HUMAN (Q9Y6I7)

Gene Name: WSB1

Synonyms: SWIP1

Organism: Homo sapiens (Human).

Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of Ubiquitination Sites:
Overview of Protein Ubiquitination Sites with Functional and Structural Information
InterPro ID Domain
IPR001496
IPR001680
IPR011046
IPR015943


The ubiquitination sites of WSB1_HUMAN

No. Position Ubiquitinated Peptide Secondary Structure Solvent Accessibility Substrate Motifs PubMed ID
131PAAPFD K KCGREN CCCCCC E ECCCCE 50.79%21906983
2208DDGNMM K VLRGHQ CCCEEE E EEECCC 27.61%21890473
3333ASLADD K MVRFWR EEEECC C EEEEEE 39.58%2190698

The interacting network mediated by proteins: WSB1_HUMAN

Metabolic pathway:
Kegg map ID Pathway
map03008Ribosome biogenesis in eukaryotes