UniprotKB/SwissProt ID: ZBT18_HUMAN (Q99592)
Gene Name: ZBTB18
Synonyms: RP58, TAZ1, ZNF238
Organism: Homo sapiens (Human).
Function: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Note=Associates with condensed chromatin.
| |
|
