UniprotKB/SwissProt ID: ZN363_HUMAN (Q96PM5)
Gene Name: RCHY1
Synonyms: ARNIP, CHIMP, PIRH2, RNF199, ZNF363
Organism: Homo sapiens (Human).
Function: Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Monoubiquitinates the translesion DNA polymerase POLH. Contributes to the regulation of the cell cycle progression. Increases AR transcription factor activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus speckle. Cytoplasm.
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