Protein Name: E3 ubiquitin-protein ligase ZNRF3
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UniprotKB/SwissProt ID: ZNRF3_HUMAN (Q9ULT6)
Gene Name: ZNRF3
Synonyms: KIAA1133, RNF203
Organism: Homo sapiens (Human).
Function: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
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Graphical Visualization of Ubiquitination Sites:
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| Overview of Protein Ubiquitination Sites with Functional and Structural Information |  |
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