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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Alpha-1-antichymotrypsin

UniprotKB/SwissProt ID: AACT_HUMAN (P01011)

Gene Name: SERPINA3

Synonyms: AACT

Organism: Homo sapiens (Human).

Function: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD00120Antichymotrypsin Bochum 1
HPRD00120Antichymotrypsin Bonn 1
HPRD00120Antichymotrypsin Isehara 1
HPRD00120Antichymotrypsin Isehara 2
HPRD00120Antichymotrypsin signal peptide polymorphism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000215

The S-nitrosylation sites of AACT_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1261IPYFRDEELS C TVVELKYTGN CCEEEECCCC C EEEEEEECCC 5.38%HC1225040305in vivo