Protein Name: Long-chain-fatty-acid--CoA ligase 4
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UniprotKB/SwissProt ID: ACSL4_HUMAN (O60488)
Gene Name: ACSL4
Synonyms: ACS4, FACL4, LACS4
Organism: Homo sapiens (Human).
Function: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane; Single-pass type III membrane protein (By similarity). Peroxisome membrane; Single-pass type III membrane protein (By similarity). Microsome membrane; Single-pass type III membrane protein (By similarity). Endoplasmic reticu
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | KEGG | H00480 | Non-syndromic X-linked mental retardation | | OMIM | 300157 | ACYL-CoA SYNTHETASE LONG-CHAIN FAMILY MEMBER 4; ACSL4 ;;FATTY ACID CoA LIGASE, LONG CHAIN 4; | | OMIM | 300387 | MENTAL RETARDATION, X-LINKED 63; MRX63 ;;MENTAL RETARDATION, X-LINKED 68; MRX68 | | HPRD | 02152 | Mental retardation, X-linked 63 | | HPRD | 02152 | Mental retardation, X-linked 68 |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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