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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Actin, cytoplasmic 1

UniprotKB/SwissProt ID: ACTB_HUMAN (P60709)

Gene Name: ACTB

Organism: Homo sapiens (Human).

Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

PDB :
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Protein disease:
Disease database Database Entry Disease information
HPRD00032Dystonia, juvenile-onset
Network with metabolic pathway:
Kegg map ID Pathway Link
map05110Vibrio cholerae infection
map05130Pathogenic Escherichia coli infection
map05131Shigellosis
map05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
map04520Adherens junction
map04670Leukocyte transendothelial migration
map04971Gastric acid secretion
map05100Bacterial invasion of epithelial cells
map05410Hypertrophic cardiomyopathy (HCM)
map05414Dilated cardiomyopathy
map05416Viral myocarditis
map04145Phagosome
map04510Focal adhesion
map04530Tight junction
map04810Regulation of actin cytoskeleton
map05132Salmonella infection
map05164Influenza A
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004000
IPR004001

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3BYH EM 12.00 A A2-375Link
3D2U X-ray 2.21 A C/G170-178Link
3LUE EM - A/B/C/D/E/F/G/H/I/J2-375Link

The S-nitrosylation sites of ACTB_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1217EIVRDIKEKL C YVALDFEQEM HHHHHHHHHH E ECCCCHHHHH 3.68%HC1125040305in vivo
2217EIVRDIKEKL C YVALDFEQEM HHHHHHHHHH E ECCCCHHHHH 3.68%HC1121278135in vitro
3272FQPSFLGMES C GIHETTFNSI CCCHHCCCCC C CHHHHHHHHH 3.65%HC0625040305in vivo
4285HETTFNSIMK C DVDIRKDLYA HHHHHHHHHC C CHHHHHHHHC 3.22%HC0219483679in vivo
5285HETTFNSIMK C DVDIRKDLYA HHHHHHHHHC C CHHHHHHHHC 3.22%HC0221278135in vitro