dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: Adenosine kinase

UniprotKB/SwissProt ID: ADK_HUMAN (P55263)

Gene Name: ADK

Organism: Homo sapiens (Human).

Function: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform 1: Nucleus. Isoform 2: Cytoplasm.

PDB :
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Network with metabolic pathway:

Kegg map ID	Pathway	Link
map00230	Purine metabolism

Graphical Visualization of S-nitrosylation Sites:

Overview of Protein S-nitrosylation Sites with Functional and Structural Information

InterPro ID	Domain
IPR001805
IPR002173
IPR011611

3D Structure Databases:


3D structure databases
Entry	Method	Resolution (A)	Chain	Positions	View
1BX4	X-ray	1.50 A	A	22-362	Link
2I6A	X-ray	2.20 A	A/B/C/D	22-362	Link
2I6B	X-ray	2.30 A	A/B	22-362	Link

The S-nitrosylation sites of ADK_HUMAN

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	Substrate Motifs	PubMed ID	Experiment
1	160	SLIANLAAAN C YKKEKHLDLE	EEEEECCCCC C CCCCCCCCHH	4.52%	HC05	19483679	in vivo
2	353	AASIIIRRTG C TFPEKPDFH-	HHHHHHHCCC C CCCCCCCCC	3.33%	HC04	24105792	-
3	353	AASIIIRRTG C TFPEKPDFH-	HHHHHHHCCC C CCCCCCCCC	3.33%	HC04	2212679 (Cys336)	in vitro
4	353	AASIIIRRTG C TFPEKPDFH-	HHHHHHHCCC C CCCCCCCCC	3.33%	HC04	22126794 (Cys336)	in vivo

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