Protein Name: Acylglycerol kinase, mitochondrial
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UniprotKB/SwissProt ID: AGK_HUMAN (Q53H12)
Gene Name: AGK
Synonyms: MULK
Organism: Homo sapiens (Human).
Function: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion membrane.
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 212350 | CATARACT AND CARDIOMYOPATHY ;;SENGERS SYNDROME;; CARDIOMYOPATHY AND CATARACT | | OMIM | 610345 | MULTISUBSTRATE LIPID KINASE; MULK ;;ACYLGLYCEROL KINASE; AGK | | OMIM | 614691 | CATARACT 38; CTRCT38 |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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