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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Aldose reductase

UniprotKB/SwissProt ID: ALDR_HUMAN (P15121)

Gene Name: AKR1B1

Synonyms: ALDR1

Organism: Homo sapiens (Human).

Function: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00040Pentose and glucuronate interconversions
map00051Fructose and mannose metabolism
map00052Galactose metabolism
map00561Glycerolipid metabolism
map00620Pyruvate metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001395
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1ABN X-ray 2.40 A A2-316Link
1ADS X-ray 1.65 A A2-316Link
1AZ1 X-ray 1.80 A A2-316Link
1AZ2 X-ray 2.90 A A2-316Link
1EF3 X-ray 2.80 A A/B2-315Link
1EL3 X-ray 1.70 A A1-316Link
1IEI X-ray 2.50 A A1-316Link
1MAR X-ray 1.80 A A2-316Link
1PWL X-ray 1.10 A A1-316Link
1PWM X-ray 0.92 A A1-316Link
1T40 X-ray 1.80 A A1-316Link
1T41 X-ray 1.05 A A1-316Link
1US0 X-ray 0.66 A A1-316Link
1X96 X-ray 1.40 A A1-316Link
1X97 X-ray 1.40 A A1-316Link
1X98 X-ray 1.30 A A1-316Link
1XGD X-ray 2.10 A A2-315Link
1Z3N X-ray 1.04 A A1-316Link
1Z89 X-ray 1.43 A A1-316Link
1Z8A X-ray 0.95 A A1-316Link
2ACQ X-ray 1.76 A A2-315Link
2ACR X-ray 1.76 A A2-315Link
2ACS X-ray 1.76 A A2-315Link
2ACU X-ray 1.76 A A2-315Link
2AGT X-ray 1.00 A A1-316Link
2DUX X-ray 1.60 A A1-316Link
2DUZ X-ray 1.60 A A1-316Link
2DV0 X-ray 1.62 A A1-316Link
2F2K X-ray 1.94 A A1-316Link
2FZ8 X-ray 1.48 A A1-316Link
2FZ9 X-ray 1.60 A A1-316Link
2FZB X-ray 1.50 A A1-316Link
2FZD X-ray 1.08 A A1-316Link
2HV5 X-ray 1.59 A A1-316Link
2HVN X-ray 1.58 A A1-316Link
2HVO X-ray 1.65 A A1-316Link
2I16 X-ray 0.81 A A1-316Link
2I17 X-ray 0.81 A A1-316Link
2IKG X-ray 1.43 A A1-316Link
2IKH X-ray 1.55 A A1-316Link
2IKI X-ray 1.47 A A1-316Link
2IKJ X-ray 1.55 A A1-316Link
2INE X-ray 1.90 A A2-315Link
2INZ X-ray 1.95 A A2-315Link
2IPW X-ray 2.00 A A2-315Link
2IQ0 X-ray 1.95 A A2-315Link
2IQD X-ray 2.00 A A2-315Link
2IS7 X-ray 1.70 A A2-315Link
2ISF X-ray 2.00 A A2-315Link
2J8T X-ray 0.82 A A1-316Link
2NVC X-ray 1.65 A A1-316Link
2NVD X-ray 1.55 A A1-316Link
2PD5 X-ray 1.60 A A1-316Link
2PD9 X-ray 1.55 A A1-316Link
2PDB X-ray 1.60 A A1-316Link
2PDC X-ray 1.65 A A1-316Link
2PDF X-ray 1.56 A A1-316Link
2PDG X-ray 1.42 A A1-316Link
2PDH X-ray 1.45 A A1-316Link
2PDI X-ray 1.55 A A1-316Link
2PDJ X-ray 1.57 A A1-316Link
2PDK X-ray 1.55 A A1-316Link
2PDL X-ray 1.47 A A1-316Link
2PDM X-ray 1.75 A A1-316Link
2PDN X-ray 1.70 A A1-316Link
2PDP X-ray 1.65 A A1-316Link
2PDQ X-ray 1.73 A A1-316Link
2PDU X-ray 1.55 A A1-316Link
2PDW X-ray 1.55 A A1-316Link
2PDX X-ray 1.65 A A1-316Link
2PDY X-ray 1.65 A A1-316Link
2PEV X-ray 0.90 A A1-316Link
2PF8 X-ray 0.85 A A1-316Link
2PFH X-ray 0.85 A A1-316Link
2PZN X-ray 1.00 A A1-316Link
2QXW X-ray 0.80 A A1-316Link
2R24 X-ray 1.75 A A1-316Link
3BCJ X-ray 0.78 A A1-316Link
3DN5 X-ray 1.45 A A1-316Link
3G5E X-ray 1.80 A A1-316Link
3GHR X-ray 1.00 A A1-316Link
3GHS X-ray 1.00 A A1-316Link
3GHT X-ray 1.10 A A1-316Link
3GHU X-ray 1.20 A A1-316Link
3LBO X-ray 1.10 A A1-316Link
3LD5 X-ray 1.27 A A1-316Link
3LEN X-ray 1.21 A A1-316Link
3LEP X-ray 0.99 A A1-316Link
3LQG X-ray 1.35 A A1-316Link
3LQL X-ray 1.13 A A1-316Link
3LZ3 X-ray 1.03 A A1-316Link
3LZ5 X-ray 0.95 A A1-316Link
3M0I X-ray 1.07 A A1-316Link
3M4H X-ray 0.94 A A1-316Link
3M64 X-ray 1.30 A A1-316Link
3MB9 X-ray 1.65 A A1-316Link
3MC5 X-ray 1.14 A A1-316Link
3ONB X-ray 1.45 A A2-316Link
3ONC X-ray 1.06 A A2-316Link
3P2V X-ray 1.69 A A1-316Link
3Q65 X-ray 2.09 A A/B1-316Link
3Q67 X-ray 1.55 A A/B1-316Link
3RX2 X-ray 1.90 A A1-316Link
3RX3 X-ray 1.90 A A1-316Link
3RX4 X-ray 2.00 A A1-316Link
3S3G X-ray 1.80 A A1-316Link
3T42 X-ray 1.28 A A1-316Link
3U2C X-ray 1.00 A A1-316Link
3V35 X-ray 1.90 A A1-316Link
3V36 X-ray 2.00 A A1-316Link
4GCA X-ray 0.90 A A2-316Link
4GQ0 X-ray 2.10 A A1-316Link
4JIR X-ray 2.00 A A1-316Link
The S-nitrosylation sites of ALDR_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1299LLSYNRNWRV C ALLSCTSHKD HHHHHCCCCC C CCHHHHCCCC 1.33%HC0922178444-
2299LLSYNRNWRV C ALLSCTSHKD HHHHHCCCCC C CCHHHHCCCC 1.33%HC0919061876-
3299LLSYNRNWRV C ALLSCTSHKD HHHHHCCCCC C CCHHHHCCCC 1.33%HC0919483679in vivo
4304RNWRVCALLS C TSHKDYPFHE CCCCCCCCHH H HCCCCCCCCC 4.58%HC1119483679in vivo