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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Annexin A2

UniprotKB/SwissProt ID: ANXA2_HUMAN (P07355)

Gene Name: ANXA2

Synonyms: ANX2, ANX2L4, CAL1H, LPC2D

Organism: Homo sapiens (Human).

Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the c

PDB :
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Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001464
IPR002389

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1W7B X-ray 1.52 A A1-339Link
1XJL X-ray 2.59 A A/B21-338Link
2HYU X-ray 1.86 A A32-338Link
2HYV X-ray 1.42 A A32-338Link
2HYW X-ray 2.10 A A/B32-338Link
4DRW X-ray 3.50 A A/B/C/D2-16Link
4HRH X-ray 3.00 A A/B2-16Link

The S-nitrosylation sites of ANXA2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1133TDEDSLIEII C SRTNQELQEI CHHHHHHHHH H HCCHHHHHHH 2.50%HC0522178444-
2133TDEDSLIEII C SRTNQELQEI CHHHHHHHHH H HCCHHHHHHH 2.50%HC0525040305in vivo
3133TDEDSLIEII C SRTNQELQEI CHHHHHHHHH H HCCHHHHHHH 2.50%HC0516648260in vivo
4133TDEDSLIEII C SRTNQELQEI CHHHHHHHHH H HCCHHHHHHH 2.50%HC0520140087in vivo
5262LENAFLNLVQ C IQNKPLYFAD HHHHHHHHHH H HCCHHHHHHH 2.42%HC1225040305in vivo