logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

UniprotKB/SwissProt ID: AT2A2_MOUSE (O55143)

Gene Name: Atp2a2

Organism: Mus musculus (Mouse).

Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Network with metabolic pathway:
Kegg map ID Pathway Link
map05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
map04260Cardiac muscle contraction
map04972Pancreatic secretion
map05410Hypertrophic cardiomyopathy (HCM)
map05414Dilated cardiomyopathy
map04020Calcium signaling pathway
map05010Alzheimer's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001757
IPR004014
IPR005782
IPR005834
IPR006068
IPR008250

The S-nitrosylation sites of AT2A2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1344RSLPSVETLG C TSVICSDKTG ECHHHHHHHH C CCEEEECCCC 2.63%MC1322865876in vivo
2349VETLGCTSVI C SDKTGTLTTN HHHHHCCCEE E ECCCCEEECC 3.95%MC1222865876in vivo
3364GTLTTNQMSV C RMFILDKVEG CEEECCCEEE E EEEECCCCCC 1.73%MC0521278135in vitro
4364GTLTTNQMSV C RMFILDKVEG CEEECCCEEE E EEEECCCCCC 1.73%MC0522865876in vivo
5377FILDKVEGDT C SLNEFSITGS EECCCCCCHH H HHHHHCCCCC 5.32%MC1321278135in vitro
6377FILDKVEGDT C SLNEFSITGS EECCCCCCHH H HHHHHCCCCC 5.32%MC1322865876in vivo
7404EVQKDDKPVK C HQYDGLVELA HHHHCHHHHC C CCHHHHHHHH 2.17%MC0122865876in vivo
8417YDGLVELATI C ALCNDSALDY HHHHHHHHHH H HEECCCCEEE 1.74%MC1322865876in vivo
9420LVELATICAL C NDSALDYNEA HHHHHHHHHE E CCCCEEECCC 2.57%MC1322865876in vivo
10447VGEATETALT C LVEKMNVFDT ECCHHHHHHH H HHHHHCCCCC 4.10%MC0724895380-
11447VGEATETALT C LVEKMNVFDT ECCHHHHHHH H HHHHHCCCCC 4.10%MC0721278135in vitro
12447VGEATETALT C LVEKMNVFDT ECCHHHHHHH H HHHHHCCCCC 4.10%MC0722865876in vivo
13471GLSKIERANA C NSVIKQLMKK HHHHHHHHCC C HHHHHHHCEE 3.80%MC0120925432in vivo
14471GLSKIERANA C NSVIKQLMKK HHHHHHHHCC C HHHHHHHCEE 3.80%MC0121278135in vitro
15471GLSKIERANA C NSVIKQLMKK HHHHHHHHCC C HHHHHHHCEE 3.80%MC0122865876in vivo
16498SRDRKSMSVY C TPNKPSRTSM CCCCEEEEEE E ECCCCCCCCE 4.83%MC0121278135in vitro
17498SRDRKSMSVY C TPNKPSRTSM CCCCEEEEEE E ECCCCCCCCE 4.83%MC0122865876in vivo
18524KGAPEGVIDR C THIRVGSTKV ECCHHHHHHH H HHHHCCCCCC 2.62%MC0321278135in vitro
19524KGAPEGVIDR C THIRVGSTKV ECCHHHHHHH H HHHHCCCCCC 2.62%MC0322865876in vivo
20560EWGSGSDTLR C LALATHDNPL HHCCCCCCCE E EEEEEECCCC 2.68%MC0222178444-
21560EWGSGSDTLR C LALATHDNPL HHCCCCCCCE E EEEEEECCCC 2.68%MC0220925432in vivo
22560EWGSGSDTLR C LALATHDNPL HHCCCCCCCE E EEEEEECCCC 2.68%MC0221278135in vitro
23560EWGSGSDTLR C LALATHDNPL HHCCCCCCCE E EEEEEECCCC 2.68%MC0220837516in vivo
24560EWGSGSDTLR C LALATHDNPL HHCCCCCCCE E EEEEEECCCC 2.68%MC0222865876in vivo
25595KYETNLTFVG C VGMLDPPRIE EECCCCEEEE E EEECCCCCCC 1.69%MC1322865876in vivo
26635GDNKGTAVAI C RRIGIFGQDE CCCHHHHHHH H HHCCCCCCCC 1.40%MC1121278135in vitro
27635GDNKGTAVAI C RRIGIFGQDE CCCHHHHHHH H HHCCCCCCCC 1.40%MC1122865876in vivo
28669ELSPSAQRDA C LNARCFARVE HCCHHHHHHH H HHCCEECCCC 3.36%MC0721278135in vitro
29875SFYQLSHFLQ C KEDNPDFDGV EEEECCCCCH H CCCCCCCCCC 5.92%MC1022865876in vivo
30998RNYLEQPGKE C VQPATKSSCS HHHCCCCCCE E EECCCCCCCC 3.82%MC0222178444-
31998RNYLEQPGKE C VQPATKSSCS HHHCCCCCCE E EECCCCCCCC 3.82%MC0224895380-
32998RNYLEQPGKE C VQPATKSSCS HHHCCCCCCE E EECCCCCCCC 3.82%MC0221278135in vitro
33998RNYLEQPGKE C VQPATKSSCS HHHCCCCCCE E EECCCCCCCC 3.82%MC0220837516in vivo