UniprotKB/SwissProt ID: B2L11_HUMAN (O43521)
Gene Name: BCL2L11
Synonyms: BIM
Organism: Homo sapiens (Human).
Function: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endomembrane system; Peripheral membrane protein (By similarity). Note=Associated with intracytoplasmic membranes (By similarity). Isoform BimEL: Mitochondrion. Note=Translocates from microtubules to motochondria on loss of cell adherence. Isoform BimL:
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PDB :
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