Protein Name: Calreticulin
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UniprotKB/SwissProt ID: CALR_MOUSE (P14211)
Gene Name: Calr
Organism: Mus musculus (Mouse).
Function: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum lumen. Cytoplasmic granule. Sarcoplasmic reticulum lumen (By similarity). Note=Associated with the lytic granules in the cytolytic T- lymphocytes.
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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