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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cystathionine beta-synthase

UniprotKB/SwissProt ID: CBS_MOUSE (Q91WT9)

Gene Name: Cbs

Organism: Mus musculus (Mouse).

Function: Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00260"Glycine, serine and threonine metabolism"
map00270Cysteine and methionine metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000644
IPR001216
IPR001926
IPR005857