Protein Name: CD2-associated protein
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UniprotKB/SwissProt ID: CD2AP_HUMAN (Q9Y5K6)
Gene Name: CD2AP
Organism: Homo sapiens (Human).
Function: Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton (By similarity). Cell projection, ruffle (By similarity). Note=Colocalizes with F- actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anapha
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | HPRD | 05026 | Glomerulosclerosis, focal segmental, 3 |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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