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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hsp90 co-chaperone Cdc37

UniprotKB/SwissProt ID: CDC37_HUMAN (Q16543)

Gene Name: CDC37

Synonyms: CDC37A

Organism: Homo sapiens (Human).

Function: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04151PI3K-Akt signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004918
IPR013855
IPR013873
IPR013874

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1US7 X-ray 2.30 A B127-378Link
2K5B NMR - B148-276Link
2W0G X-ray 1.88 A A148-276Link

The S-nitrosylation sites of CDC37_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1308YESLPEELQK C FDVKDVQMLQ HHHCCHHHHH H HHHHHHHHHH 1.96%HC0219483679in vivo
2336PTDAKYHMQR C IDSGLWVPNS HHHHHHHHHH H HHHCCCCCCC 1.97%HC0219483679in vivo