UniprotKB/SwissProt ID: CDC42_MOUSE (P60766)
Gene Name: Cdc42
Organism: Mus musculus (Mouse).
Function: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Midbody (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (By similarity). Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as c
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