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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: UMP-CMP kinase 2, mitochondrial

UniprotKB/SwissProt ID: CMPK2_MOUSE (Q3U5Q7)

Gene Name: Cmpk2

Synonyms: Tyki

Organism: Mus musculus (Mouse).

Function: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00240Pyrimidine metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of CMPK2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
144PRRFTVELPD C SLTHFVLGDA   3.20%MC0720925432in vivo
2243ARAVLDLVDQ C PKEVQKGKFQ   4.50%MC0220925432in vivo
3422MTYQRMENPS C HLVDASPSRE   2.80%MC0321278135in vitro