Protein Name: CCR4-NOT transcription complex subunit 1
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UniprotKB/SwissProt ID: CNOT1_HUMAN (A5YKK6)
Gene Name: CNOT1
Synonyms: CDC39, KIAA1007, NOT1
Organism: Homo sapiens (Human).
Function: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, P-body. Nucleus (Probable). Note=NANOS2 promotes its localization to P-body (By similarity).
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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