Protein Name: Cofilin-1
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UniprotKB/SwissProt ID: COF1_MOUSE (P18760)
Gene Name: Cfl1
Organism: Mus musculus (Mouse).
Function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Colocal
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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