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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cytochrome c oxidase subunit 1

UniprotKB/SwissProt ID: COX1_MOUSE (P00397)

Gene Name: Mtco1

Synonyms: COI, mt-Co1

Organism: Mus musculus (Mouse).

Function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion inner membrane; Multi-pass membrane protein.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000883

The S-nitrosylation sites of COX1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1199VLAQLITRGE C YGLHAFVVPI HHHHHHHHHH H HHHHHHHHHH 3.25%MC0721278135in vitro
2392TWTANAGIEE C RMACGGHGYS HHHHHHHHHH H HHHHHHHHHC 14.02%MC0521278135in vitro
3498ASTNLEWLHG C PPPYHTFEEP CCCCCCCCCC C CCCCCCCCCC 2.96%MC0421278135in vitro
4531VDLVRASEAH C HYVTVKVFAD   %MC0221278135in vitro
5559RAVQAVLRNL C LLYSLYGISQ   %MC1321278135in vitro
6559RAVQAVLRNL C LLYSLYGISQ   %MC1322865876in vivo