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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Carbamoyl-phosphate synthase [ammonia], mitochondrial

UniprotKB/SwissProt ID: CPSM_HUMAN (P31327)

Gene Name: CPS1

Organism: Homo sapiens (Human).

Function: Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion. Nucleus, nucleolus.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD01995Carbamoyl phosphate synthetase i deficiency
HPRD01995Pulmonary hypertension, familial persistent, of the newborn, susceptibility to
Network with metabolic pathway:
Kegg map ID Pathway Link
map00250"Alanine, aspartate and glutamate metabolism"
map00330Arginine and proline metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000991
IPR001317
IPR002474
IPR005479
IPR005480
IPR005481
IPR005483
IPR006274
IPR006275
IPR011607
IPR011702
IPR011761
IPR013816
IPR013817

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2YVQ X-ray 1.98 A A1343-1478Link

The S-nitrosylation sites of CPSM_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1600YALGGLGSGI C PNRETLMDLS CCCCCCCEEE E CCHHHHHHHH 2.52%HC0622178444-
2600YALGGLGSGI C PNRETLMDLS CCCCCCCEEE E CCHHHHHHHH 2.52%HC0618335467-
3600YALGGLGSGI C PNRETLMDLS CCCCCCCEEE E CCHHHHHHHH 2.52%HC0619366988-