Protein Name: Protein cereblon
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UniprotKB/SwissProt ID: CRBN_HUMAN (Q96SW2)
Gene Name: CRBN
Organism: Homo sapiens (Human).
Function: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Membrane; Peripheral membrane protein (By similarity).
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | KEGG | H00768 | Nonsyndromic autosomal recessive mental retardation (NS-ARMR) | | OMIM | 607417 | MENTAL RETARDATION, AUTOSOMAL RECESSIVE 2; MRT2 ;;MENTAL RETARDATION, AUTOSOMAL RECESSIVE 2A | | OMIM | 609262 | CEREBLON; CRBN | | HPRD | 16750 | Mental retardation, nonsyndromic, autosomal recessive, 2A |
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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