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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dehydrogenase/reductase SDR family member 4

UniprotKB/SwissProt ID: DHRS4_MOUSE (Q99LB2)

Gene Name: Dhrs4

Synonyms: D14Ucla2

Organism: Mus musculus (Mouse).

Function: Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Peroxisome (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00830Retinol metabolism
map04146Peroxisome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002198
IPR002347

The S-nitrosylation sites of DHRS4_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
189GEGLSVTGIV C HVGKAEDREK HHHHHHHHHH H CCCCEEEECC 1.71%MC0721278135in vitro
289GEGLSVTGIV C HVGKAEDREK HHHHHHHHHH H CCCCEEEECC 1.71%MC0722865876in vivo
3210ELAPKNIRVN C LAPGLIKTRF HHHHCCCCCH H HHHHHHHHCC 2.91%MC0321278135in vitro
4210ELAPKNIRVN C LAPGLIKTRF HHHHCCCCCH H HHHHHHHHCC 2.91%MC0322865876in vivo