UniprotKB/SwissProt ID: DOK1_HUMAN (Q99704)
Gene Name: DOK1
Organism: Homo sapiens (Human).
Function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform 1: Cytoplasm. Nucleus. Isoform 3: Cytoplasm, perinuclear region.
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