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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dual specificity protein phosphatase 3

UniprotKB/SwissProt ID: DUS3_MOUSE (Q9D7X3)

Gene Name: Dusp3

Organism: Mus musculus (Mouse).

Function: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04010MAPK signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000340
IPR000387

The S-nitrosylation sites of DUS3_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1124AHKNGRVLVH C REGYSRSPTL HCCCCCEEEE C CCCCCHHHHH 3.10%MC0221278135in vitro
2171GPNDGFLAQL C QLNDRLAKEG CCCHHHHHHH H HHHHHHHHCC 2.62%MC0421278135in vitro