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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Excitatory amino acid transporter 2

UniprotKB/SwissProt ID: EAA2_MOUSE (P43006)

Gene Name: Slc1a2

Synonyms: Eaat2, Glt1

Organism: Mus musculus (Mouse).

Function: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein.

Network with metabolic pathway:
Kegg map ID Pathway Link
map05014Amyotrophic lateral sclerosis (ALS)
map04724Glutamatergic synapse
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001991

The S-nitrosylation sites of EAA2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1373SAGTLPVTFR C LEDNLGIDKR HHHHHHHHHH H HHHHCCCCCC 4.22%MC0322588120-
2561TLAANGKSAD C SVEEEPWKRE EECCCCCCCC C CCCCCCCCCC 4.99%MC0322588120-