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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Elongation factor 1-alpha 1

UniprotKB/SwissProt ID: EF1A1_MOUSE (P10126)

Gene Name: Eef1a1

Synonyms: Eef1a

Organism: Mus musculus (Mouse).

Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus (By similarity). Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map05134Legionellosis
map03013RNA transport
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000795
IPR004160
IPR004161
IPR004539
IPR009000
IPR009001

The S-nitrosylation sites of EF1A1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1234SGTTLLEALD C ILPPTRPTDK CCHHHHHHHH H CCCCCCCCCC 3.42%MC0224926564-
2234SGTTLLEALD C ILPPTRPTDK CCHHHHHHHH H CCCCCCCCCC 3.42%MC0220925432in vivo
3234SGTTLLEALD C ILPPTRPTDK CCHHHHHHHH H CCCCCCCCCC 3.42%MC0221278135in vitro
4411IVDMVPGKPM C VESFSDYPPL EEEEEECCCE E ECCCCCCCCC 4.10%MC1319101475-
5411IVDMVPGKPM C VESFSDYPPL EEEEEECCCE E ECCCCCCCCC 4.10%MC1321278135in vitro