UniprotKB/SwissProt ID: EIF3A_MOUSE (P23116)
Gene Name: Eif3a
Synonyms: Csma, Eif3, Eif3s10
Organism: Mus musculus (Mouse).
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Note=Centrosomin-A is found in the centrosome. Centrosomin-B is found in the nucleus.
| |
|