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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Neutrophil elastase

UniprotKB/SwissProt ID: ELNE_HUMAN (P08246)

Gene Name: ELANE

Synonyms: ELA2

Organism: Homo sapiens (Human).

Function: Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD00554Cyclic hematopoiesis
HPRD00554Neutropenia, severe congenital, autosomal dominant 1
Network with metabolic pathway:
Kegg map ID Pathway Link
map05322Systemic lupus erythematosus
map05202Transcriptional misregulation in cancer
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001254
IPR001314
IPR009003

The S-nitrosylation sites of ELNE_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1151QGRRLGNGVQ C LAMGWGLLGR CCCCCCCCCE E EEEEEEEECC 2.13%HC0125040305in vivo