UniprotKB/SwissProt ID: ESRP2_HUMAN (Q9H6T0)
Gene Name: ESRP2
Synonyms: RBM35B
Organism: Homo sapiens (Human).
Function: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
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