Protein Name: Filamin-C
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UniprotKB/SwissProt ID: FLNC_HUMAN (Q14315)
Gene Name: FLNC
Synonyms: ABPL, FLN2
Organism: Homo sapiens (Human).
Function: Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fr
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | KEGG | H00595 | Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myot | | OMIM | 102565 | FILAMIN C; FLNC ;;FILAMIN, GAMMA;; FILAMIN 2; FLN2;; ACTIN-BINDING PROTEIN 280, AUTOSOMAL FO | | OMIM | 609524 | MYOPATHY, MYOFIBRILLAR, FILAMIN C-RELATED ;;MFM, FILAMIN C-RELATED;; FILAMINOPATHY, AUTOSOMA | | OMIM | 614065 | MYOPATHY, DISTAL, 4; MPD4 | | HPRD | 00018 | Filaminopathy, autosomal dominant |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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