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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ferritin heavy chain

UniprotKB/SwissProt ID: FRIH_MOUSE (P09528)

Gene Name: Fth1

Synonyms: Fth

Organism: Mus musculus (Mouse).

Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map00860Porphyrin and chlorophyll metabolism
map04978Mineral absorption
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001519
IPR008331
IPR009040
IPR009078
IPR012347
IPR014034

The S-nitrosylation sites of FRIH_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1131LATDKNDPHL C DFIETYYLSE HHHHCCCHHH H HHHHHHHHHH 3.50%MC0920925432in vivo