UniprotKB/SwissProt ID: G3BP1_MOUSE (P97855)
Gene Name: G3bp1
Synonyms: G3bp
Organism: Mus musculus (Mouse).
Function: May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasmic granule (By similarity). Cell membrane (By similarity). Nucleus (By similarity). Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially
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