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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

UniprotKB/SwissProt ID: GBB2_HUMAN (P62879)

Gene Name: GNB2

Organism: Homo sapiens (Human).

Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, perinuclear region.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04723Retrograde endocannabinoid signaling
map04724Glutamatergic synapse
map04725Cholinergic synapse
map04726Serotonergic synapse
map04727GABAergic synapse
map04728Dopaminergic synapse
map05032Morphine addiction
map04062Chemokine signaling pathway
map04151PI3K-Akt signaling pathway
map05034Alcoholism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001632
IPR001680
IPR011046
IPR015943

The S-nitrosylation sites of GBB2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
125RNQIRDARKA C GDSTLTQITA HHHEECCEEE C CCCCEEEEEE 7.54%HC0321278135in vitro
2204PDGRTFVSGA C DASIKLWDVR CCCCEEEEEE C CCEEEEEECC 5.25%HC0121278135in vitro
3317VLAGHDNRVS C LGVTDDGMAV EEECCCCCEE E EEECCCCCEE 3.33%HC0421278135in vitro