Protein Name: Gamma-aminobutyric acid receptor-associated protein-like 2
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UniprotKB/SwissProt ID: GBRL2_HUMAN (P60520)
Gene Name: GABARAPL2
Synonyms: FLC3A, GEF2
Organism: Homo sapiens (Human).
Function: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus (By similarity). Cytoplasmic vesicle, autophagosome.
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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