UniprotKB/SwissProt ID: GLRX3_HUMAN (O76003)
Gene Name: GLRX3
Synonyms: PICOT, TXNL2
Organism: Homo sapiens (Human).
Function: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3
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PDB :
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